IsoMut publications
Methodology:
- Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut.
Pipek O, Ribli D, Molnár J, Póti Á, Krzystanek M, Bodor A, Tusnády GE, Szallasi Z, Csabai I, Szüts D.
BMC Bioinformatics. 2017 Jan 31;18(1):73. doi: 10.1186/s12859-017-1492-4.
PMID: 28143617 Free PMC Article
IsoMut in practice:
- Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.
Póti Á, Berta K, Xiao Y, Pipek O, Klus GT, Ried T, Csabai I, Wilcoxen K, Mikule K, Szallasi Z, Szüts D.
Br J Cancer. 2018 Nov;119(11):1392-1400. doi: 10.1038/s41416-018-0312-6. Epub 2018 Nov 14.
PMID: 30425352 - Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions.
Zámborszky J, Szikriszt B, Gervai JZ, Pipek O, Póti Á, Krzystanek M, Ribli D, Szalai-Gindl JM, Csabai I, Szallasi Z, Swanton C, Richardson AL, Szüts D.
Oncogene. 2017 Feb 9;36(6):746-755. doi: 10.1038/onc.2016.243. Epub 2016 Jul 25. Erratum in: Oncogene. 2017 Jun 26;:.
PMID: 27452521 Free PMC Article - A comprehensive survey of the mutagenic impact of common cancer cytotoxics.
Szikriszt B, Póti Á, Pipek O, Krzystanek M, Kanu N, Molnár J, Ribli D, Szeltner Z, Tusnády GE, Csabai I, Szallasi Z, Swanton C, Szüts D.
Genome Biol. 2016 May 9;17:99. doi: 10.1186/s13059-016-0963-7.
PMID: 27161042 Free PMC Article