Research project
The Systems Biology of Reproduction Research Group studies the obstetrical, biological, immunological, pathological and systems biological aspects of the ‘Great Obstetrical Syndromes’. The importance of the topic is supported by the fact that 70% of pregnancies and 15% of clinically recognized pregnancies end with miscarriage, and 25% of pregnant women have obstetrical syndromes that may have severe impact on the health of both mother and child. The research group studies and characterizes signal transduction pathways that may play key role in the development of miscarriages and obstetrical syndromes. The focus is on the systems biological investigation of the complex and overlapping dysregulation of maternal-fetal immuntolerance, trophoblast invasion and differentiation. Besides describing molecular pathways and signaling networks of pregnancy complications, our investigations may also reveal novel biomarkers and drug targets.


Scientific collaborations
1. Hungarian Academy of Sciences, Research Centre for Natural Sciences
2. Semmelweis University, First Department of Pathology and Experimental Cancer Research; Department of Genetics, Cell- and Immunobiology; Maternity Clinic
3. Eötvös Loránd University, Institute of Biology
4. Hungarian Academy of Sciences, Biological Research Centre, Institute of Genetics
5. Perinatology Research Branch, National Institutes of Health (Detroit, MI, USA)
6. Wayne State University (Detroit, MI, USA)
7. University of Southern California (Los Angeles, CA, USA)
8. Zymo Research Corporation (Irvine, CA, USA)
9. Ben Gurion University (Beer Sheva, Israel)
10. University of Basel (Basel, Switzerland)


Media presence
http://novumtv.hu/adasaink/2015-12-26
http://www.zymoresearch.com/webinar/epigenetics/epigenetics-in-human-health-and-disease


Principal investigator
Nándor Gábor Than, MD PhD, senior research fellow
MTMT: https://vm.mtmt.hu//search/slist.php?lang=0&AuthorID=10011696
Google Scholar: https://scholar.google.hu/citations?user=ECdMsVAAAAAJ&hl=hu&oi=ao
http://mta.hu/lendulet/than-nandor-gabor-lendulet-osztondijas-kutato-106439


Research group
Zsolt Gelencsér, PhD, informatician
Kata Juhász, PhD, research fellow
Katalin Karászi, MSc, PhD student
Barbara Kocsis-Deák, MSc, PhD student
Nóra Novák, BSc, MSc student
Helga Popovics, BSc, biologist